To remove punctuation from a string in JavaScript, do this:
string.replace(/[\p{P}\p{S}]/gu, '')
Here's how you do it:
const string = 'Hello World!,.;:#%$^&?+-*=';
const noPunctuation = string.replace(/[\p{P}\p{S}]/gu, '');
console.log(noPunctuation); // Hello World